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What is Mesothelioma?

Mesothelioma is an uncommon form of cancer, usually associated with previous exposure to asbestos, which affects the pleura, a sac which surrounds the lungs, the peritoneum, the lining of the abdominal cavity, or the pericardium, a sac that surrounds the heart.

In this disease, malignant (cancerous) cells are found in the mesothelium, a protective sac that covers most of the body's internal organs. Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or have been exposed to asbestos dust and fiber in other ways, such as by washing the clothes of a family member who worked with asbestos, or by home renovation using asbestos cement products.

Diagnosis of Mesothelioma.

Diagnosing mesothelioma is often difficult, because the symptoms are similar to those of a number of other conditions. Diagnosis begins with a review of the patient's medical history, including any history of asbestos exposure. A complete physical examination may be performed, including x-rays of the chest or abdomen and lung function tests. A CT (or CAT) scan or an MRI may also be useful. A CT scan is a series of detailed pictures of areas inside the body created by a computer linked to an x-ray machine. In an MRI, a powerful magnet linked to a computer is used to make detailed pictures of areas inside the body. These pictures are viewed on a monitor and can also be printed.

A biopsy is needed to confirm a diagnosis of mesothelioma. In a biopsy, a surgeon or a medical oncologist (a doctor who specializes in diagnosing and treating cancer) removes a sample of tissue for examination under a microscope by a pathologist. A biopsy may be done in different ways, depending on where the abnormal area is located. If the cancer is in the chest, the doctor may perform a thoracoscopy. In this procedure, the doctor makes a small cut through the chest wall and puts a thin, lighted tube called a thoracoscope into the chest between two ribs. Thoracoscopy allows the doctor to look inside the chest and obtain tissue samples. If the cancer is in the abdomen, the doctor may perform a peritoneoscopy. To obtain tissue for examination, the doctor makes a small opening in the abdomen and inserts a special instrument called a peritoneoscope into the abdominal cavity. If these procedures do not yield enough tissue, more extensive diagnostic surgery may be necessary.

If the diagnosis is mesothelioma, the doctor will want to learn the stage (or extent) of the disease. Staging involves more tests in a careful attempt to find out whether the cancer has spread and, if so, to which parts of the body. Knowing the stage of the disease helps the doctor plan treatment.

Mesothelioma is described as localized if the cancer is found only on the membrane surface where it originated. It is classified as advanced if it has spread beyond the original membrane surface to other parts of the body, such as the lymph nodes, lungs, chest wall, or abdominal organs.

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Causes of Mesothelioma Cancer

Mesothelioma
is the growth of malignant cells in mesothelium, the thin membrane covering the body’s internal organs. This mesothelium lining covers the pleural, peritoneal and pericardial cavities. Pleura is a membrane covering the lungs and it is the most common location where mesothelioma cancer occurs also known as pleural mesothelioma. Peritoneum, the protective covering that lines the abdominal cavity may also develop malignant tumors and cause peritoneal mesothelioma.

Mesothelioma is one of the rarest cancers in the world that is caused only by exposure to asbestos. Its exposure can be direct, by inhalation of asbestos or indirect exposure in which the asbestos particles are inhaled from the clothing, hair, equipment or other articles that were previously exposed to asbestos.

Causes of Mesothelioma
Asbestos is a naturally occurring fibrous mineral that is mined in different parts of the world due to its wide utility in various industries. However, it is a deadly carcinogen too and a mojor cause of mesothelioma and asbestosis.

Asbestos fibers are known to cause cancer of the mesothelium. Asbestos is the fibrous form of several minerals and hydrous silicates of magnesium found under ground. There are 3 types of asbestos, the blue one, the while one and the brown one. Of all these 3 types, the blue one also called amphibole, long and thin in structure is more carcinogenic than white or chrysolite asbestos or the brown one known as amosite.

However, in some cases the brown asbestos has also been found to cause mesothelioma. And it is for this reason that people exposed to asbestos even for a short period are vulnerable to the disease.

Pleural Mesothelioma
Asbestos fibers are very fine and easily make their way to the lungs where they settle down in the parenchyma of the lung and penetrate the pleura that later develops malignant mesothelial plaques.

Pleura, which anchors lungs to the chest cavity, is itself a double-layered membrane. The inner layer called visceral pleura surrounds the lungs, while the outer one, known as parietal pleura, forms the lining of the pleural or chest cavity. The two pleural layers are filled with a fluid that helps them to slide over each other as we breathe. As the disease progresses, the delicate pleural membranes thicken and press the lungs. A fluid secreted by the malignant cells, pleural effusion, may also collect between visceral and parietal pleurae that causes problem in breathing and other complications.

Peritoneum Mesothelioma
The asbestos fibers may also cause cancer in the peritoneum, known as peritoneal mesothelioma. This leads to thickening of the membranes surrounding abdominal organs and collection of a fluid, ascites in the abdominal cavity making it swell.

Though it is yet not clear how peritoneal mesothelioma develops, it is believed that from lungs, the asbestos fibers are transported to abdomen and its organs by the lymphatic system or they may be deposited in the gut through saliva contaminated by the asbestos fibers.

Pericardial Mesothelioma
This is the rarest type of mesothelioma cancer that comprises of only 5% of all the mesothelioma cases. Like other types of mesothelioma cancer, pericardial mesothelioma is also caused by the inhalation of asbestos dust and fibers. The lining of the chest cavity which protects the heart is known as pericardium. It is provided with a natural fluid or mucous that provide continuous lubrication to the heart so that it can work properly and perform its functions.

It is a very deadly disease that destroys the tissues around the heart and diminishes the survival chances of the patient. As the asbestos particles settle further into the lining of the chest or pericardial, the cancer spreads in the body. It destroys the heart tissues and muscles that is very hazardous to life and proves fatal for the patient.

Article Tags: Asbestos, Mesothelioma Cancer, Mesothelioma, Mesothelioma Types, Mesothelioma Treatments, Mesothelioma Asbestos, Mesothelioma Cuases

About the Author:

Laura Russell is a professional health writer having expertise in the field of Mesothelioma Cancer. To view more of her articles, please visit: Mesothelioma Cancer Info